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6 methods scientists are now exploring to slow aging

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Researchers have yet to find the Fountain of Youth, but their findings have given more insight into the science behind aging.

Aging is one of them. Most Important Risk Factor In many diseases, including cancer and neurodegenerative diseases such as Alzheimer’s disease, the older you get, the more likely you are to have multiple chronic conditions.

Diet and lifestyle choices are important ways to live longer. However, our family history can also play a role. “Our genes are amazing enough to allow us to approach the age of 90 if we live a healthy lifestyle. Dr. Thomas Perls said: An aging expert and director of the Boston University School of Medicine.

Although lifespan is directly related to human health behavior, scientists studying regeneration and aging have developed a greater understanding of how our bodies change over time. In consideration of, guava health We’ve put together a list of six areas of scientific research in development aimed at slowing down aging. Researchers have yet to find the Fountain of Youth, but their findings have given more insight into the science behind aging.

intermittent fasting

was Fasting Popularity Soars, ranked among Google’s top trending diet searches. Intermittent fasting aims to regulate your body’s metabolism by limiting how much and how often you eat. But could it also be an anti-aging weapon?

of The health benefits of intermittent fasting are well established Recent studies have shown promising results in animals as well. However, it is not clear whether this leads to similar longevity effects, or whether there are also specific types (or combinations) of foods that must be consumed during these periods. It has shown mixed responses in terms of efficacy, and human trials have yet to prove long-term efficacy. Intermittent fasting works by switching the metabolism. Fasting triggers the body to switch its energy source from glucose, which is stored in the liver, to ketones, substances produced when cells are low on glucose.

Dr. Richard J. Hodes, Director of the National Institute on Aging, said: Effectively substantiated research When mice ate one meal per day and had the longest fasting period, they lived longer and improved the outcomes of common age-related liver disease and metabolic disorders.

Researchers continue to extend these findings with laboratory studies, and many hope there may be potential anti-aging benefits in humans, including reducing age-related metabolic disorders. doing.

medical professional with tablet

rejuvenation of the immune system

As we age, our immune system can gradually decline over time. to develop strategies to keep them alive and make them less susceptible to disease.

An experimental combination therapy of two anti-aging compounds known as “Mechanical targets of rapamycin” OR mTOR inhibitors have been shown to prolong and rejuvenate aging immune systems and organs in mice.

and 2018 clinical trial Funded by the pharmaceutical company Novartis, 264 volunteers aged 65 and older were given one or both drugs or assigned to a control group that included a placebo. People who took low doses of both drugs reported an average of 1.49 respiratory infections over the year, compared with 2.41 in the placebo group.

The immune system can play a major role in mitigating many of the expected physical ailments. Regulate homeostasis and fight infection This area is of interest to scientists trying to combat the aging process, from wrinkles to cancer. Their research includes therapies focused on replenishing aging immune system tissues or cells, immunosuppressive strategies, and various approaches that target specific cell types.

Scientist doing research with a microscope

Targeting cellular senescence

As we age, our cells also age and become less functional. Cellular senescence is the process by which cells lose their ability to divide and replicate. Senescent cells are known as ‘zombie cells’ because they are resistant to cell death. They can no longer function and damage neighboring cells.

The accumulation of these zombie cells is a hallmark of aging that leads to the deterioration of body organs and tissues and the development of age-related diseases. Laboratory tests show that removing these cells can improve tissue function. Although the exact role of senescent cells in aging is still not fully understood, they play a key role in the degenerative changes that occur in the body over time.

Senolytics are a class of drugs that selectively eliminate senescent cells that may help slow the aging process. In 2016, two separate research groups A new senolytic drugselectively kills senescent cells. Research led by the University of Arkansas We have shown that the drug ABT-263 (Navitoclax) can selectively kill senescent cells and rejuvenate tissues.scientists from Weizmann Institute of Science Israel used a similar drug, ABT-737, to kill senescent cells in the lungs and skin of mice.

and A 2018 study led by Mayo Clinic researcher James Kirkland They tested a combination of dasatinib, which is used to treat some forms of leukemia, and quercetin, a plant flavanol found in fruits and vegetables. It was determined whether it could delay physical dysfunction. It has been shown to be effective, and future research may prove that such compounds are effective in humans.

Two doctors examine a series of x-rays

bone loss recovery

of U.S. Preventive Services Task Force recommends that women over the age of 65 and women at risk for osteoporosis have regular bone measurements. Bones become thinner and weaker over time, increasing the risk of osteoporosis and making them more susceptible to fractures and fractures.

A 2014 study showed that resveratrol, a natural phytoestrogen, has potential. anti-aging therapy for bonesA study focused on bone mass and biomechanical properties in 20 rats found that resveratrol was able to increase bone microstructure and mechanical properties.

Interestingly, incorporating resveratrol into dietary supplements and foods has become a popular anti-aging option, reportedly resveratrol treatment It may have beneficial effects, such as slowing bone loss.

Scientist looking at microscope in lab

human tissue engineering

the field of human tissue engineering is an interdisciplinary study aimed at developing biological substitutes to maintain or restore damaged cell function. Examples of successful but experimental and expensive regenerative therapies include bladder assist, small arteries, skin grafts, cartilage and even complete tracheal reconstruction.

Researcher at Stanford University School of Medicine found that aged mice regained youthful strength after pre-existing muscle stem cells received a rejuvenating protein treatment.

In the early 2000s, researchers faced the following challenges: Challenges of organ transplantation, and alternative tissue and organ reconstruction appeared. It may one day be possible to isolate a patient’s cells from a small biopsy, expand the number of cells in culture, and transplant them.

Geneticist working in the lab

cell regeneration

Institute of Zoology, Chinese Academy of Sciences I found a way to include A gene called kat7 may play an important role in cellular senescence. The study found that when the kat7 gene in mice was inactivated or disabled, lifespan was increased by 25% and overall appearance and grip strength were improved.

Stanford University continues Yamanaka Factor Research, proteins known to transform mature cells into iPS cells, or induced pluripotent stem cells. iPS cells are the cornerstone of regenerative research because they can grow and develop into any type of cell in the body. During this process, the cells return to a more active state, shedding the “memory” of their previous identity and reverting to a younger state.

of UCLA’s Interdisciplinary Center for Stem Cell Research propose that iPS cells could be used to create cancer-free cells in leukemia patients or to develop neurons to treat neurological disorders.

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