Researchers have also shown improvements in physiological markers after DBS.
In the first Canadian study, Sunnybrook researchers found that deep brain stimulation (DBS), a type of brain surgery, is safe and effective in treating severe and treatment-resistant post-traumatic stress disorder (PTSD). provided early evidence that it could be.
Researchers have also found promising biomarkers that may be future indicators of an individual’s response to DBS.
Groundbreaking research published scientific progress.
PTSD is a debilitating illness that affects the lives of more than 3 million Canadians. It can occur in individuals who have experienced traumatic events such as war, violence, accidents, and abuse. Patients may suffer from distressing or frightening thoughts, flashbacks, or nightmares, which can be long-lasting and can greatly affect their quality of life.
Results from this Phase I clinical trial suggest that DBS can improve symptoms in PTSD patients. Six months after surgery, he had symptom improvement in 3 of her 4 patients in a pilot study, as measured by the Clinician-Administered PTSD Scale (CAPS), a structured interview considered gold You can now better manage your fear response. A standard for evaluating symptoms of PTSD. On average, the patient’s scale decreased by 55%.
“Approximately 20 to 30 percent of patients diagnosed with PTSD do not respond to conventional treatments such as psychotherapy and medication, known as treatment-resistant PTSD.” Dr. Nil Lipsman, Principal Investigator and Director of the Harquail Center for Neuromodulation, Sunnybrook. “Although this study is still in its early stages, these preliminary results are encouraging and suggest that DBS may be a breakthrough approach to managing treatment-resistant PTSD.”
DBS is a neurosurgical procedure that directly targets dysfunctional brain circuits. It involves inserting thin electrodes into deep brain structures that cause associated symptoms and electrically stimulating them with a pacemaker-like device implanted in the chest. DBS is an established treatment for movement disorders such as Parkinson’s disease, essential tremor, and obsessive-compulsive disorder.
In this study, the researchers used a direct-to-brain approach, targeting a known role in PTSD and previously validated as a successful target in preclinical studies pioneered by Sunnybrook scientists. It targeted the subgeneric herpes zoster and uniculum fasciculus, regions of the brain that were previously identified.
In addition to clinical assessment and neuroimaging, patients in this study measured their sweating responses to stressful stimuli in both threatening and non-threatening situations before and after DBS to assess fear conditioning and extinction. A psychophysiological evaluation was also completed.
The researchers found that those who had the greatest ability to decouple fear responses from stimuli over time were more likely to have better clinical outcomes. This suggests that in the future, this assessment may be a useful biomarker in predicting who will respond best to surgery.
“After DBS, some patients showed improved responses, no increase in sweating, and a sense of fear. are very encouraged by the results of these world-first studies.” Dr. Clement HamaniPrincipal Investigator, Senior Scientist and Research Director of the Hurvitz Brain Sciences Research Program at Sunnybrook Research institute. “After years of preclinical research, these results represent an important step forward in our mission to find more accurate treatments for PTSD and improve the quality of life for patients and their families.”
A generous philanthropic investment in Sunnybrook’s Harquail Center for Neuromodulation, including lead support from the Harquail family, is a catalyst for advancing this research and other groundbreaking neuromodulation work at Sunnybrook. was supported by the DANA Foundation. In 2018, Sunnybrook researchers received her $1.25 million grant through the Government of Canada’s Veterans and Family Welfare Fund to investigate innovative treatments for PTSD at her Harquail Center for Neuromodulation in Canada. Assisted her with a neuromodulation program dedicated to PTSD.
Find out more about Deep Brain Stimulation at Sunnybrook below. sunnybrook.ca/dbs
learn more about Sunnybrook’s Neuromodulation Harquay Center
Sunnybrook Health Science Center