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Gastric Cancer Risk by eEF1A Dimethylation

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chronic eradication therapy Helicobacter pylori (Helicobacter pylori) infection reduces the risk of gastric cancer (GC) but does not eliminate it completely, and there is a need for markers in patients who are still at high risk of gastric cancer after eradication therapy. The researchers found that dimethylation of eEF1A lysine 55 (eEF1AK55me2) Helicobacter pylori status, eradication therapy outcomes, and GC risk.

Dimethylation of eEF1A may predict gastric cancer after eradication therapy

In their observational study, BMC Gastroenterologyresearchers have found evidence that Helicobacter pylori Infection enhanced eEF1A dimethylation in the gastric mucosa. They also suggested that “accumulation of dimethyl-eEF1A in the basal region of the mucosa may contribute to GC risk through regulation of reprogramming factors.” Helicobacter pylori eradicated gastric mucosa.

The study retrospectively enrolled 115 patients who underwent upper gastrointestinal endoscopy. Helicobacter pylori– positive, 29 people H. Helicobacter pylori– Negative, 75 had undergone post-eradication treatment. The researchers used immunofluorescence staining to measure her eEF1A dimethyl levels in gastric mucosal cells.

According to the report, the dimethylation level of eEF1A was significantly increased at the surface (P.=.0031) and the basis (P.=.0036) area Helicobacter pylori– Positive gastric mucosa compared to negative mucosa. Of note, surface eEF1A dimethyl levels were significantly reduced after eradication therapy (P.=.005), and the basal level was not affected.

Further analysis showed that eEF1A high dimethylation in the basal region was an independent predictor for the development of GC (odds ratio, 3.6611; 95% CI, 1.350-12.949; P.=.0441). Furthermore, researchers identified a relationship between eEF1A dimethylation and expression of two of his reprogramming factors, Oct4 and Nanog.

Ultimately, the authors of this study concluded that increased eEF1A dimethylation and Helicobacter pylori May increase risk of infections stomach cancerthen Helicobacter pylori Eradication therapy.

Related: New insights into biology, origin of deadly gastric and esophageal cancers

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