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Manifestations, Outcomes of Adult Onset Still Disease

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According to the results of a retrospective study presented at the American College of Rheumatology Convergence 2022, patients with adult-onset static disease (AOSD) can present with elevated inflammatory markers, leukocytosis, and anemia.

Investigators examined demographics, objective laboratory findings, and outcomes of 185 patients with AOSD aged 18 years or older. Using the International Classification of Diseases (10th revision) code M06.1, he identified a patient diagnosed with her AOSD in 1 of 185 hospitals from 2016 to 2021.

They found that the incidence of AOSD ranges from 0.16 to 0.21 per 100,000 people. The average age of the participants he was 47 years old and nearly 70% of the participants were female. Overall mortality was 3.2%.

Elevated inflammatory markers observed in these patients included erythrocyte sedimentation rate (55.111 +/- 36.52), c-reactive protein (12.26 +/- 27.48), and ferritin (71411.23 +/- 11536.60). I was. Additional presentations included leukocytosis (12.15 +/- 5.86) and unspecified anemia (23%).

Additionally, approximately 24% of patients required admission to an intensive care unit (ICU). Coexisting pneumonia was present in her 11.9% of patients. This was associated with increased her ICU admission (likelihood ratio 7.4, p = .007) but not with increased mortality.

“Our study establishes patient demographics and common objective findings to better understand and diagnose this rare disease,” the authors concluded. “The incidence increased over time, suggesting increased awareness and improved diagnosis.”

— Lee Precopio


Bui C, Collins T, Venkat K, Ayutyanont N, Vickery K, Kubomoto S. Adult-onset Still’s disease: an objective symptom-outcome retrospective study. Paper published: American College of Rheumatology Convergence 2022; November 10-14, 2022. Philadelphia, Pennsylvania. Accessed 2 November 2022. https://acrabstracts.org/abstract/adult-onset-stills-disease-a-retrospective-study-of-objective-manifestations-and-outcomes/

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