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Mysterious Changes Identified in The Brains of People Who Get Migraines : ScienceAlert

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Scientists may have just found a major new clue that could help solve the frustrating ongoing mystery of migraines.

Using ultra-high resolution MRIresearchers found that the perivascular space (the fluid-filled space around the blood vessels in the brain) is abnormally enlarged in patients experiencing both chronic and episodic migraines. Did.

Although its relationship to migraine and its role have not yet been established, this finding may point to unexplored avenues for future research.

The findings were presented at the 108th Scientific Conference and Annual Meeting of the Radiological Society of North America.

Chronic migraine and episodic migraine In the absence of aura, there are large changes in the perivascular space in a brain region called the semioval centroid. ” says medical scientist Wilson Shue University of Southern California, Los Angeles.

“These changes have never been reported before.”

Migraines, stop chopping up words, it’s hell to live with. The aspects of intolerable headaches are well known, but they can also cause migraines. dizzyvisual impairment (known as aura), photosensitivity, and nausea until vomiting. The cause of migraine is unknown, there is no cure, and the condition is often unresponsive to treatment.

Conditions affect estimates 10% of the world populationFinding the cause and more effective management strategies would therefore improve the lives of millions of people.

Xu and his colleagues were interested in the perivascular space around the semiovule, a central region of brain white matter just below the cerebral cortex. The function of these spaces is not fully understood.They play a role in the drainage of fluid shifts and their expansion Signs of a bigger problem.

“The perivascular space is part of the fluid clearance system in the brain.” Xu says“Studying how they contribute to migraines may help us better understand the complexities of how migraines occur.

He and his colleagues recruited 20 migraine patients between the ages of 25 and 60. Ten experienced chronic migraine without aura and 10 experienced episodic migraine. In addition, his 5 healthy patients who had not experienced migraine were included as a control group.

The team excluded patients with cognitive impairment, claustrophobia, brain tumors, or previous brain surgery. Did. Most hospital scanners only have magnets up to 3 Tesla.

“As far as we know, this [the] It is the first study to use ultra-high-resolution MRI to study migraine-induced microvascular changes in the brain, especially around them. ” Xu explains.

“Because 7T MRI can produce images of the brain with much higher resolution and superior quality than other MRI types, it can be used to show much smaller changes that occur in brain tissue after a migraine headache.”

Scanning revealed a significantly enlarged perivascular space in the semioval center of migraine patients compared with controls.

Researchers also found differences in the distribution of a type of lesion known as white matter hyperintense in migraine patients. These are caused by small patches of dead or partially dead tissue starved by restricted blood flow and are fairly normal.

Although there was no difference in the frequency of these lesions between migraine and control patients, deep lesions were more severe in migraine patients.

The researchers believe this suggests that an expansion of the perivascular space may lead to the future development of more white matter lesions.

Although the nature of the association between perivascular space enlargement and migraine is unclear, results suggest that migraine involves problems with brain plumbing. glymphatic system It is involved in the removal of waste products from the brain and nervous system. It utilizes perivascular channels for transport.

Further work is needed to investigate this correlation, but even identifying it is promising.

“Our findings will inspire future large-scale studies to continue investigating how alterations in the brain’s microvessels and blood supply contribute to different migraine types. It may help.” Shu says.

“Ultimately, this could help develop new, personalized methods for diagnosing and treating migraine.”

This research 108th Annual Meeting of the Radiological Society of North America.

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