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Study shows reinfection protection for COVID-19 vaccines

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new study in denmark suggest that the COVID-19 vaccine offers excellent protection against reinfection in people already infected with the virus (up to 9 months in some cases). Studies examining the protection provided during alpha, delta, and omicron waves pros medicine.

The study population included more than 700,000 people previously infected with SARS-CoV-2, identified in the Danish National Registry between 1 January 2020 and 31 January 2022. rice field. Time since vaccination, using unvaccinated citizens as a reference.

VE for reinfection following the type of COVID-19 vaccine administered in Denmark peaked at 71% (95% confidence interval) [CI]-Inf to 100%), 94% (95% CI, 92% to 96%) ≥104 days post-vaccination during the alpha period, 14 to 43 days post-vaccination during the delta period, and 60% (95% CI, 58% to 62%) 14–43 days post-vaccination during the Omicron period.

“Although vaccination appears to protect against reinfection with the Omicron subspecies to some extent, these findings suggest that previously infected individuals benefit from COVID-19 vaccination during all three subspecies periods. It is relevant to public health because it shows,” the authors said.

New variants make VE estimates slippery

In an email to CIDRAP News, first study author Katrine Findup Nielsen, MS, said the study intentionally excluded vaccinees who became infected within 90 days but were administered after January 2022. He said he was not considering a booster dose.

Gregory Poland, M.D., Ph.D., of the Vaccine Research Group at the Mayo Clinic in Rochester, Minnesota, said the study confirms that vaccination provides protection against reinfection for at least several weeks, but the new variant is a VE for researchers. complicates the study of

“The problem is that this is a multi-dimensional matrix of what you’ve been infected with, what vaccines you’ve had, how many times and how long ago you’ve had them, and what’s currently prevalent,” Poland said. .

Although he believes that previous natural infection with COVID-19 and two doses of vaccination make it very unlikely that someone re-infected will die, and that subsequent cases will make hospitalization very unlikely. , the risk of developing post-COVID-19 acute and post-COVID symptoms is real. .

“The risk of prolonging COVID-19 is 20% to 25%. The risk of complications from acute infection varies from 20 to almost 100 cases per 1,000 cases,” said Poland. “Remember, 1 of her 298 Americans has died of her COVID-19.”

Caution before consecutive holidays

Ziyad Al-Aly, MD, director of research and education services for the Veterans Affairs St. Louis Health Care System, said: Recent research on reinfection in vaccinated persons. his message is clear.

“Viruses are always overtaking us and betraying us. It’s a hybrid immunity of immunity and natural infection, not a complete defense.”

Both Al-Aly and Poland said their messages, albeit somber, are important as Americans begin the six-week holiday season, which begins tomorrow with Thanksgiving.

First, not everyone can do it, but both recommended getting all vaccines and boosters in the proposed timeline as explained by the Centers for Disease Control and Prevention.

Al-Aly said he recommends wearing a proper mask while traveling on vacation, and Poland says a proper mask is just as important as wearing a seatbelt in a car. Wearing a tight-fitting mask such as the N-95 provides the best protection.

“There will be people reading this who will die or be hospitalized before Christmas,” Poland said. “So we have to balance known risks against known benefits and make data-driven choices.”

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